APOE4 effects in middle-aged EC and PVC Lead Investigator: Tal Nuriel Institution : Columbia University Medical Center E-Mail : tn2283@cumc.columbia.edu Proposal ID : 1079 Proposal Description: (pathology free) individuals and have been genotyped for APOE. I have brain tissue from individuals with one copy of APOE4, but it is much more difficult to find brain tissue from individuals with two copies of APOE4. In particular, I need entorhinal cortex (BA28) and primary visual cortex (BA17) tissue. Any help I could get with this would be greatly appreciated.